Drop-out model optimization on degraded DNA samples
نویسندگان
چکیده
منابع مشابه
Detecting STR peaks in degraded DNA samples
Human identification from DNA is typically based on 13 short-tandem repeat (STR) alleles. Commercial kits used in forensic casework rely on the detection of these alleles in DNA samples acquired from an individual. However, the process itself is slow (it can take up to 2 days when conducting a laboratory analysis or 1 hour when using Rapid DNA systems) and has been designed to operate on pristi...
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Obtaining informative short tandem repeat (STR) profiles from degraded DNA samples is a challenging task usually undermined by locus or allele dropouts and peak-high imbalances observed in capillary electrophoresis (CE) electropherograms, especially for those markers with large amplicon sizes. We hereby show that the current STR assays may be greatly improved for the detection of genetic marker...
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ژورنال
عنوان ژورنال: Forensic Science International: Genetics Supplement Series
سال: 2015
ISSN: 1875-1768
DOI: 10.1016/j.fsigss.2015.09.147